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<table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CD2AP</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q9JLQ0%20or%20Q9Y5K6">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q9JLQ0,Q9Y5K6">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2FEI">2FEI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J6F">2J6F</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J6K">2J6K</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J6O">2J6O</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J7I">2J7I</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3AA6">3AA6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LK4">3LK4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3U23">3U23</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4WCI">4WCI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4X1V">4X1V</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class=""><a href="Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/14258">CD2AP</a></span>, CMS, CD2-associated protein, CD2 associated protein</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/604241">604241</a>; <a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1330281">1330281</a>; <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=7663">7663</a>; <a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD2AP">CD2AP</a>; <a href="Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000198087">CD2AP - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chromosome 6 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 76.486926455093px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 82.5px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">6p12.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">47,477,789 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">47,627,263 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">Chromosome 17 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 128.20298047837px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 134.2px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">17|17 B3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">43,103,842 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">43,187,556 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Human_genome" title="Human genome">Human</a></b></th><th><b><a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000198087">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">jejunal mucosa</li><br><li style="line-height: 137%;">mucosa of colon</li><br><li style="line-height: 137%;">mucosa of sigmoid colon</li><br><li style="line-height: 137%;">duodenum</li><br><li style="line-height: 137%;">rectum</li><br><li style="line-height: 137%;">glomerulus</li><br><li style="line-height: 137%;">amniotic fluid</li><br><li style="line-height: 137%;">metanephric glomerulus</li><br><li style="line-height: 137%;">oral cavity</li><br><li style="line-height: 137%;">germinal epithelium</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000061665">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">gastrula</li><br><li style="line-height: 137%;">gastric mucosa</li><br><li style="line-height: 137%;">mucous cell of stomach</li><br><li style="line-height: 137%;">renal corpuscle</li><br><li style="line-height: 137%;">epithelium of stomach</li><br><li style="line-height: 137%;">medullary collecting duct</li><br><li style="line-height: 137%;">urothelium</li><br><li style="line-height: 137%;">decidua</li><br><li style="line-height: 137%;">aortic valve</li><br><li style="line-height: 137%;">secondary oocyte</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000198087">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008013">beta-catenin binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017124">SH3 domain binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044877">protein-containing complex binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005200">structural constituent of cytoskeleton</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008022">protein C-terminus binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005172">vascular endothelial growth factor receptor binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045296">cadherin binding</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031941">filamentous actin</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005911">cell-cell junction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001726">ruffle</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030139">endocytic vesicle</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031252">cell leading edge</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015629">actin cytoskeleton</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005856">cytoskeleton</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000249">regulation of actin cytoskeleton reorganization</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032911">negative regulation of transforming growth factor beta1 production</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016050">vesicle organization</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006930">substrate-dependent cell migration, cell extension</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051301">cell division</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007049">cell cycle</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016477">cell migration</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048259">regulation of receptor-mediated endocytosis</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043161">proteasome-mediated ubiquitin-dependent protein catabolic process</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900182">positive regulation of protein localization to nucleus</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007015">actin filament organization</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051058">negative regulation of small GTPase mediated signal transduction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098609">cell-cell adhesion</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0065003">protein-containing complex assembly</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050714">positive regulation of protein secretion</a></li></ul>

</div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=23607&rn=1">23607</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12488&rn=1">12488</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000198087;db=core">ENSG00000198087</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000061665;db=core">ENSMUSG00000061665</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9Y5K6">Q9Y5K6</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9JLQ0">Q9JLQ0</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_012120">NM_012120</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009847">NM_009847</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_036252">NP_036252</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033977">NP_033977</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr6:47477789-47627263">Chr 6: 47.48 – 47.63 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr17:43103842-43187556">Chr 17: 43.1 – 43.19 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="PubMed" title="PubMed">PubMed</a> search</th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18037479" class="extiw external" title="d:Q18037479">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18248198" class="extiw external" title="d:Q18248198">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table>

<p><b>CD2-associated protein</b> is a <a href="Protein" title="Protein">protein</a> that in humans is encoded by the <i>CD2AP</i> <a href="Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid10339567_5-0" class="reference"><a href="#cite_note-pmid10339567-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Function">Function</h2></div>

<p>This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, <a href="SH3_domain" title="SH3 domain">SH3 domains</a>, and a <a href="Proline" title="Proline">proline</a>-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to <a href="Membrane_ruffling" title="Membrane ruffling">membrane ruffles</a>, <a href="Lipid_raft" title="Lipid raft">lipid rafts</a>, and the leading edges of cells. It is implicated in dynamic <a href="Actin_remodeling" title="Actin remodeling">actin remodeling</a> and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.<sup id="cite_ref-entrez_6-1" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>

<p>CD2AP has been shown to <a href="Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with:

</p>

<li><a href="Nephrin" title="Nephrin">Nephrin</a>,<sup id="cite_ref-pmid15331416_11-0" class="reference"><a href="#cite_note-pmid15331416-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> and</li>

<ul><li><a href="Focal_segmental_glomerulosclerosis" title="Focal segmental glomerulosclerosis">Focal segmental glomerulosclerosis</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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<li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000198087">GRCh38: Ensembl release 89: ENSG00000198087</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

<li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000061665">GRCm38: Ensembl release 89: ENSMUSG00000061665</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

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</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=23607">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite></span>

</li>

<li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=12488">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite></span>

</li>

<li id="cite_note-pmid10339567-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10339567_5-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFKirschGeorgescuIshimaruHanafusa1999" class="citation journal cs1">Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26861">"CMS: An adapter molecule involved in cytoskeletal rearrangements"</a>. <i>Proc Natl Acad Sci USA</i>. <b>96</b> (11): <span class="nowrap">6211–</span>6. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1999PNAS...96.6211K">1999PNAS...96.6211K</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.96.11.6211">10.1073/pnas.96.11.6211</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26861">26861</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10339567">10339567</a>.</cite></span>

</li>

<li id="cite_note-entrez-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23607">"Entrez Gene: CD2AP CD2-associated protein"</a>.</cite></span>

</li>

<li id="cite_note-pmid15128873-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15128873_7-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFHaglundIvankovic-DikicShimokawaKruh2004" class="citation journal cs1">Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". <i>J. Cell Sci</i>. <b>117</b> (Pt 12): <span class="nowrap">2557–</span>68. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.01148">10.1242/jcs.01148</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15128873">15128873</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:14083271">14083271</a>.</cite></span>

</li>

<li id="cite_note-pmid11067845-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11067845_8-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFKirschGeorgescuShishidoLangdon2001" class="citation journal cs1">Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (Feb 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M005784200">"The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction"</a>. <i>J. Biol. Chem</i>. <b>276</b> (7): <span class="nowrap">4957–</span>63. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M005784200">10.1074/jbc.M005784200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11067845">11067845</a>.</cite></span>

</li>

<li id="cite_note-pmid12559036-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid12559036_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid12559036_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFCormontMetónMariMonzo2003" class="citation journal cs1">Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". <i>Traffic</i>. <b>4</b> (2): <span class="nowrap">97–</span>112. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0854.2003.40205.x">10.1034/j.1600-0854.2003.40205.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12559036">12559036</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:38612642">38612642</a>.</cite></span>

</li>

<li id="cite_note-pmid11733557-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11733557_10-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFSchwarzSimonsReiserSaleem2001" class="citation journal cs1">Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P (Dec 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200981">"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin"</a>. <i>J. Clin. Invest</i>. <b>108</b> (11): <span class="nowrap">1621–</span>9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1172%2FJCI12849">10.1172/JCI12849</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200981">200981</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11733557">11733557</a>.</cite></span>

</li>

<li id="cite_note-pmid15331416-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15331416_11-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFLehtonenLehtonenKudlickaHolthöfer2004" class="citation journal cs1">Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618613">"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin"</a>. <i>Am. J. Pathol</i>. <b>165</b> (3): <span class="nowrap">923–</span>36. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0002-9440%2810%2963354-8">10.1016/S0002-9440(10)63354-8</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618613">1618613</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15331416">15331416</a>.</cite></span>

</li>

</ol></div></div>

<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>

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<ul><li><cite id="CITEREFBonaldoLennonSoares1997" class="citation journal cs1">Bonaldo MF, Lennon G, Soares MB (1997). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">"Normalization and subtraction: two approaches to facilitate gene discovery"</a>. <i>Genome Res</i>. <b>6</b> (9): <span class="nowrap">791–</span>806. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">10.1101/gr.6.9.791</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8889548">8889548</a>.</cite></li>

<li><cite id="CITEREFDustinOlszowyHoldorfLi1998" class="citation journal cs1">Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS (1998). <a rel="nofollow" class="external text" href="https://zenodo.org/record/1065005">"A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts"</a>. <i>Cell</i>. <b>94</b> (5): <span class="nowrap">667–</span>77. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2981608-6">10.1016/S0092-8674(00)81608-6</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9741631">9741631</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:18042803">18042803</a>.</cite></li>

<li><cite id="CITEREFLehtonenOraOlkkonenGeng2000" class="citation journal cs1">Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M006624200">"In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2"</a>. <i>J. Biol. Chem</i>. <b>275</b> (42): <span class="nowrap">32888–</span>93. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M006624200">10.1074/jbc.M006624200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10913159">10913159</a>.</cite></li>

<li><cite id="CITEREFLiRuotsalainenTryggvasonShaw2000" class="citation journal cs1">Li C, Ruotsalainen V, Tryggvason K, Shaw AS, Miner JH (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fajprenal.2000.279.4.F785">"CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere"</a>. <i>Am. J. Physiol. Renal Physiol</i>. <b>279</b> (4): F785–92. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fajprenal.2000.279.4.F785">10.1152/ajprenal.2000.279.4.F785</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10997929">10997929</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:37166239">37166239</a>.</cite></li>

<li><cite id="CITEREFKirschGeorgescuShishidoLangdon2001" class="citation journal cs1">Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M005784200">"The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction"</a>. <i>J. Biol. Chem</i>. <b>276</b> (7): <span class="nowrap">4957–</span>63. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M005784200">10.1074/jbc.M005784200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11067845">11067845</a>.</cite></li>

<li><cite id="CITEREFSchwarzSimonsReiserSaleem2002" class="citation journal cs1">Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P (2002). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200981">"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin"</a>. <i>J. Clin. Invest</i>. <b>108</b> (11): <span class="nowrap">1621–</span>9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1172%2FJCI12849">10.1172/JCI12849</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200981">200981</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11733557">11733557</a>.</cite></li>

<li><cite id="CITEREFScottZappacostaKimAnnan2002" class="citation journal cs1">Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202783200">"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1"</a>. <i>J. Biol. Chem</i>. <b>277</b> (31): <span class="nowrap">28238–</span>46. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202783200">10.1074/jbc.M202783200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12029088">12029088</a>.</cite></li>

<li><cite id="CITEREFBadourZhangShiMcGavin2003" class="citation journal cs1">Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900516-2">"The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse"</a>. <i>Immunity</i>. <b>18</b> (1): <span class="nowrap">141–</span>54. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900516-2">10.1016/S1074-7613(02)00516-2</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12530983">12530983</a>.</cite></li>

<li><cite id="CITEREFCormontMetónMariMonzo2003" class="citation journal cs1">Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". <i>Traffic</i>. <b>4</b> (2): <span class="nowrap">97–</span>112. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0854.2003.40205.x">10.1034/j.1600-0854.2003.40205.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12559036">12559036</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:38612642">38612642</a>.</cite></li>

<li><cite id="CITEREFLynchWinataLyonsHughes2003" class="citation journal cs1">Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M211407200">"A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton"</a>. <i>J. Biol. Chem</i>. <b>278</b> (24): <span class="nowrap">21805–</span>13. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M211407200">10.1074/jbc.M211407200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12672817">12672817</a>.</cite></li>

<li><cite id="CITEREFHutchingsClarksonChalkleyBarclay2003" class="citation journal cs1">Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M302540200">"Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85"</a>. <i>J. Biol. Chem</i>. <b>278</b> (25): <span class="nowrap">22396–</span>403. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M302540200">10.1074/jbc.M302540200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12690097">12690097</a>.</cite></li>

<li><cite id="CITEREFKimWuGreenWinkler2003" class="citation journal cs1">Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS (2003). "CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility". <i>Science</i>. <b>300</b> (5623): <span class="nowrap">1298–</span>300. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003Sci...300.1298K">2003Sci...300.1298K</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1081068">10.1126/science.1081068</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12764198">12764198</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7106967">7106967</a>.</cite></li>

<li><cite id="CITEREFSchulzeMann2004" class="citation journal cs1">Schulze WX, Mann M (2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M309909200">"A novel proteomic screen for peptide-protein interactions"</a>. <i>J. Biol. Chem</i>. <b>279</b> (11): <span class="nowrap">10756–</span>64. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M309909200">10.1074/jbc.M309909200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14679214">14679214</a>.</cite></li>

<li><cite id="CITEREFHaglundIvankovic-DikicShimokawaKruh2004" class="citation journal cs1">Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". <i>J. Cell Sci</i>. <b>117</b> (Pt 12): <span class="nowrap">2557–</span>68. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.01148">10.1242/jcs.01148</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15128873">15128873</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:14083271">14083271</a>.</cite></li>

<li><cite id="CITEREFLehtonenLehtonenKudlickaHolthöfer2004" class="citation journal cs1">Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618613">"Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin"</a>. <i>Am. J. Pathol</i>. <b>165</b> (3): <span class="nowrap">923–</span>36. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0002-9440%2810%2963354-8">10.1016/S0002-9440(10)63354-8</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618613">1618613</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15331416">15331416</a>.</cite></li>

<li><cite id="CITEREFRushMoritzLeeGuo2005" class="citation journal cs1">Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". <i>Nat. Biotechnol</i>. <b>23</b> (1): <span class="nowrap">94–</span>101. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnbt1046">10.1038/nbt1046</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15592455">15592455</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7200157">7200157</a>.</cite></li>

<li><cite id="CITEREFCowardFosterPattonNi2005" class="citation journal cs1">Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA (2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1681%2FASN.2004030172">"Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes"</a>. <i>J. Am. Soc. Nephrol</i>. <b>16</b> (3): <span class="nowrap">629–</span>37. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1681%2FASN.2004030172">10.1681/ASN.2004030172</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15659563">15659563</a>.</cite></li></ul>

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<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

<ul><li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CD2AP"><i>CD2AP</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CD2AP"><i>CD2AP</i></a> gene details page in the <a href="UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul>

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